Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Pedigree Analysis01:35

Pedigree Analysis

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Perisylvian magnetoencephalografic impairments in patients with autism spectrum disorders].

Revista de neurologia·2018
Same author

Estimation of neutron-equivalent dose in organs of patients undergoing radiotherapy by the use of a novel online digital detector.

Physics in medicine and biology·2012
Same author

[Neurolinguistic aspects in autism spectrum disorders. Neuroanatomical and functional relations].

Revista de neurologia·2010
Same author

[A study of autism spectrum disorders and language disorders using magnetoencephalography. The scientific contribution of Dr. Muñoz Yunta].

Revista de neurologia·2009
Same author

Magnetoencephalographic pattern of epileptiform activity in children with early-onset autism spectrum disorders.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2008
Same author

[In memoriam. Cristobal Lamote de Grignon i Nicolau (1913-2006)].

Revista de neurologia·2007

Related Experiment Video

Updated: Jul 7, 2026

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

[Autism, epilepsy and genetics].

J A Muñoz-Yunta1, M Palau-Baduell, B Salvadó-Salvadó

  • 1Unidad de Neuropediatría, Servicio de Pediatría, Hospital del Mar, Barcelona. 10030amy@telefonica.net

Revista De Neurologia
|March 21, 2008
PubMed
Summary
This summary is machine-generated.

Autism and epilepsy share a strong connection, with many autistic children experiencing seizures or subclinical epileptiform activity. This neurobiological link may involve imbalances in brain chemicals like glutamate and GABA.

More Related Videos

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

Related Experiment Videos

Last Updated: Jul 7, 2026

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Context:

  • Autism spectrum disorder (ASD) exhibits a significantly higher prevalence of epilepsy compared to other developmental disorders, with estimates ranging from 7% to 42%.
  • Clinical epilepsy affects a substantial portion of autistic children, between 40% and 47%, and can emerge at any age.
  • Epileptogenic phenomena during nervous system development can severely impact cognitive function consolidation in autistic individuals.

Purpose:

  • To explore the neurobiological underpinnings of the relationship between autism and epilepsy.
  • To investigate the role of excitatory and inhibitory neurotransmitter systems in this comorbidity.
  • To examine potential genetic factors contributing to the co-occurrence of autism and epilepsy.

Summary:

  • Epileptiform discharges, even without clinical seizures, can disrupt neurodevelopment in autistic children.
  • Behavioral regression in 10-50% of autistic children may stem from epileptogenic origins, irrespective of observable seizures.
  • The association between pervasive developmental disorders and epilepsy is explained by neurobiological factors, including imbalances in glutamate and GABA systems.

Impact:

  • Understanding the neurobiological basis of epilepsy in autism can inform targeted interventions.
  • Identifying genetic candidates may lead to novel diagnostic and therapeutic strategies for comorbid conditions.
  • This research highlights the critical interplay between neurodevelopment, epilepsy, and autism, emphasizing the need for integrated care approaches.