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Neonatal Pial Surface Electroporation
Published on: May 7, 2014
Neonatal pulmonary sequestration: clinical experience with transumbilical arterial embolization
Byong Sop Lee1, Jin Taek Kim, Ellen Ai-Rhan Kim
1Department of Pediatrics, Division of Neonatology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Pediatric Pulmonology
|February 28, 2008
Summary
Pulmonary sequestration (PS) outcomes in neonates are unclear. Transumbilical arterial embolization (TUE) showed higher regression in solid-type PS, but more research is needed.
Area of Science:
- Neonatal Medicine
- Pediatric Surgery
- Radiology
Background:
- Pulmonary sequestration (PS) is a rare congenital lung malformation.
- The natural history and treatment guidelines for antenatal PS are not well-established.
Purpose of the Study:
- To describe clinical outcomes in neonates with PS.
- To evaluate the efficacy of transumbilical arterial embolization (TUE) for PS.
Main Methods:
- Retrospective review of 30 neonatal PS cases (1998-2006).
- Analysis of antenatal ultrasound, postnatal chest CT, and TUE outcomes.
- Follow-up assessment of lesion regression and complications.
Main Results:
- Six of 26 (23%) antenatally diagnosed PS lesions regressed spontaneously.
- Transumbilical arterial embolization (TUE) achieved complete or partial regression in 82% of intrapulmonary PS cases.
- Regression rate was significantly higher for solid-type (100%) versus mixed-type (25%) PS (P = 0.006).
- Complications of TUE were transient and without long-term morbidity.
Conclusions:
- Transumbilical arterial embolization (TUE) is a potentially effective treatment for neonatal pulmonary sequestration, particularly solid-type lesions.
- Further comparative studies are necessary to confirm the long-term efficacy and safety of TUE for PS.
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