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Related Experiment Video

Updated: Jul 7, 2026

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

Lysozyme-dextran core-shell nanogels prepared via a green process.

Juan Li¹, Shaoyong Yu, Ping Yao

¹The Key Laboratory of Molecular Engineering of Polymer and Department of Macromolecular Science, Fudan University, Shanghai 200433, China.

Langmuir : the ACS Journal of Surfaces and Colloids

|February 28, 2008

Summary

Researchers developed stable lysozyme-dextran nanogels using Maillard and heat-gelation processes. These novel nanogels show potential for drug delivery, particularly for protonated drugs like ibuprofen.

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Last Updated: Jul 7, 2026

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Published on: April 16, 2018

Area of Science:

Biomaterials Science
Nanotechnology
Polymer Chemistry

Background:

Developing novel nanocarriers for drug delivery is crucial.
Protein-polysaccharide conjugates offer unique properties for biomaterial applications.

Purpose of the Study:

To develop a novel method for preparing lysozyme-dextran nanogels.
To characterize the nanogels' properties and assess their drug loading capabilities.

Main Methods:

Lysozyme-dextran conjugates synthesized via Maillard reaction.
Nanogel formation induced by heat-gelation above lysozyme denaturation temperature.
Characterization of nanogel size, swelling ratio, and stability.
Drug loading studies using ibuprofen as a model drug.

Main Results:

Spherical nanogels with ~200 nm hydrodynamic diameter and ~30 swelling ratio achieved.
Nanogel solutions exhibited excellent stability across storage, pH, and ionic strength variations.
Optimal electrostatic and hydrophobic interactions observed for loading protonated ibuprofen.
Demonstrated applicability of the formation mechanism for other protein-dextran nanogels.

Conclusions:

A robust method for creating stable protein-dextran nanogels was established.
These nanogels are promising for targeted drug delivery, especially for positively charged molecules.
The developed platform is versatile for fabricating various protein-based nanostructures.