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Published on: March 8, 2018
Endothelial dysfunction and microvascular complications in type 1 diabetes mellitus
Seon Mi Jin1, Chung Il Noh, Sei Won Yang
1Department of Pediatrics, Eulji Medical Center, Seoul, Korea.
Journal of Korean Medical Science
|February 28, 2008
Summary
Endothelial dysfunction and early atherosclerosis are common in type 1 diabetes mellitus (DM). Impaired vascular function, not structural changes, is linked to microvascular complications in these patients.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Diabetology
Background:
- Type 1 diabetes mellitus (DM) is associated with vascular complications.
- Early detection of atherosclerosis and endothelial dysfunction is crucial for managing DM.
Purpose of the Study:
- To investigate the association between vascular endothelial function, early atherosclerotic changes, and microvascular complications in young adults with type 1 DM.
Main Methods:
- Flow-mediated dilation (FMD) of the brachial artery and carotid intima-media thickness (IMT) were measured in 48 type 1 DM patients and 22 controls.
- Microvascular complications (neuropathy, nephropathy, retinopathy) were assessed in DM patients.
Main Results:
- Type 1 DM patients exhibited significantly lower FMD and increased IMT compared to controls.
- Diabetic patients with microvascular complications showed significantly lower FMD compared to those without complications.
- No significant differences in IMT or other metabolic markers were found between complicated and non-complicated diabetic patients.
Conclusions:
- Endothelial dysfunction is a common manifestation in type 1 DM and is associated with microvascular complications.
- Endothelial dysfunction appears to be an early event in atherosclerosis and a key factor in the pathogenesis of microvascular complications in type 1 DM.
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