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Posttranscription regulation of prostate cancer growth

Li Shen1, Roberto Pili

  • 1Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA.

Cancer Journal (Sudbury, Mass.)
|February 28, 2008
PubMed

Insights

Targeted therapies for prostate cancer are advancing by focusing on molecular mechanisms like apoptosis and cell signaling. This review highlights key drug targets and chromatin modifiers, such as histone deacetylase inhibitors, for therapeutic intervention.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate cancer progression is linked to abnormal protein expression and function.
  • Understanding molecular mechanisms offers potential therapeutic gene targets.

Purpose of the Study:

  • To review key molecular targets and posttranscriptional strategies for prostate cancer therapy.
  • To highlight the role of chromatin modifiers, like histone deacetylase inhibitors, in therapeutic intervention.

Main Methods:

  • Review of preclinical and clinical studies on targeted therapeutic approaches for prostate cancer.
  • Focus on signal transduction pathways, including apoptosis, growth factors, and androgen receptor signaling.
  • Examination of transcriptional and posttranscriptional gene regulation strategies.

Main Results:

  • Identification of multiple "drugable" targets from mRNA transcription to protein function.
  • Prostate cancer signal transduction cascade targets often promote survival, inhibit apoptosis, and drive angiogenesis.
  • Emerging role of histone deacetylase inhibitors in gene regulation and protein modification.

Conclusions:

  • Targeted therapies offer promising avenues for prostate cancer treatment.
  • Exploiting molecular targets and posttranscriptional modifications can overcome cancer progression.
  • Histone deacetylase inhibitors represent a significant area for therapeutic development in prostate cancer.

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