Related Experiment Video
Updated: Jul 7, 2026

09:43
Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
Published on: October 14, 2019
[The commonest neuroendocrine GIT tumors--carcinoids]
Rozhledy V Chirurgii : Mesicnik Ceskoslovenske Chirurgicke Spolecnosti
|February 29, 2008
Summary
Gastrointestinal (GI) carcinoids are malignant tumors. Early diagnosis of ileal carcinoids is challenging due to absent symptoms, but PET CT aids detection and follow-up.
Area of Science:
- Gastroenterology
- Oncology
- Surgical Oncology
Background:
- Carcinoids are common malignant tumors of the gastrointestinal (GI) tract.
- Understanding their characteristics and management is crucial for patient outcomes.
Observation:
- A five-year review of GI carcinoids at a specific clinic was conducted.
- A case of ileal carcinoid presenting with acute abdomen symptoms was analyzed.
Findings:
- Nine patients with GI carcinoids underwent surgery.
- The overall five-year survival rate with comprehensive therapy was 89.9%.
- Positron Emission Tomography-Computed Tomography (PET CT) proved valuable for diagnosing and monitoring an ileocecal carcinoid case.
Implications:
- Ileal carcinoids often lack early clinical symptoms, complicating preoperative diagnosis.
- PET CT is a beneficial imaging modality for diagnosing and following up GI carcinoids.
- Timely diagnosis and integrated management strategies are essential for improving survival rates in GI carcinoid patients.
Related Concept Videos
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates these...
Metastasis
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Cancer-Critical Genes I: Proto-oncogenes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Mitogens and the Cell Cycle
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...