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Updated: Jul 7, 2026

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries
Published on: February 25, 2016
Nitric oxide release mediated by calix[4]hydroquinones.
Eranda Wanigasekara1, Carmine Gaeta, Placido Neri
1Dipartimento di Chimica, Università di Salerno, Via Ponte don Melillo, I-84084 Fisciano (Salerno), Italy.
Calix[4]monohydroquinone efficiently releases nitric oxide (NO) gas through a one-electron reduction process. The system regenerates the hydroquinone form, enabling repeated NO generation cycles for sustained nitric oxide delivery.
Area of Science:
- Supramolecular Chemistry
- Materials Science
Background:
- Calix[4]monohydroquinone serves as a supramolecular system.
- Nitric oxide (NO) gas generation is crucial for various applications.
Purpose of the Study:
- To investigate the NO gas generation mechanism using calix[4]monohydroquinone.
- To explore the recyclability of the supramolecular system for sustained NO release.
Main Methods:
- Utilized a one-electron reduction scheme involving a NO+ subsetcalix[4]monohydroquinone complex.
- Investigated the regeneration of calix[4]monohydroquinone after NO release using sodium borohydride (NaBH4).
Main Results:
- NO gas was released from the complex without external reducing agents.
- The generated calix[4]monoquinone was reduced back to calix[4]monohydroquinone using NaBH4.
- The system demonstrated reusability for multiple NO-releasing cycles.
Conclusions:
- Calix[4]monohydroquinone is an effective supramolecular system for controlled NO gas generation.
- The facile regeneration of the hydroquinone form allows for sustainable and repeatable NO release.
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