Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decrease in phase slip rates and phase cone structures during seizure evolution and epileptogenic activities derived from microgrid ECoG data.

Current research in neurobiology·2024
Same author

Increased Phase Cone Turnover in 80-250 Hz Bands Occurs in the Epileptogenic Zone During Interictal Periods.

Frontiers in human neuroscience·2021
Same author

Safety of slow-pulsed transcranial electrical stimulation in acute spike suppression.

Annals of clinical and translational neurology·2019
Same author

Oscillatory Patterns of Phase Cone Formations near to Epileptic Spikes Derived from 256-Channel Scalp EEG Data.

Computational and mathematical methods in medicine·2019
Same author

EEG source imaging of epileptic activity at seizure onset.

Epilepsy research·2018
Same author

Corrigendum to "In vitro susceptibility to the pro-apoptotic effects of TIMP-3 gene delivery translates to greater in vivo efficacy versus gene delivery for TIMPs-1 or -2" [Lung Cancer 53 (3) (September 2006) 273-284].

Lung cancer (Amsterdam, Netherlands)·2016

Related Experiment Video

Updated: Jul 7, 2026

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue
13:14

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue

Published on: October 26, 2014

Dense array EEG: methodology and new hypothesis on epilepsy syndromes.

Mark D Holmes1

  • 1Regional Epilepsy Center, Department of Neurology, University of Washington, Harborview Medical Center, Seattle, Washington 98104, USA. mdholmes@u.washington.edu

Epilepsia
|May 28, 2008
PubMed
Summary

Dense array electroencephalography (EEG) offers improved spatial resolution for pinpointing seizure origins. This advanced technique aids in localizing epileptic discharges, potentially reducing the need for invasive procedures.

More Related Videos

Performing Behavioral Tasks in Subjects with Intracranial Electrodes
12:10

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
09:00

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Published on: April 15, 2015

Related Experiment Videos

Last Updated: Jul 7, 2026

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue
13:14

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue

Published on: October 26, 2014

Performing Behavioral Tasks in Subjects with Intracranial Electrodes
12:10

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
09:00

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Published on: April 15, 2015

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Epileptology

Background:

  • Standard electroencephalography (EEG) uses limited electrodes, hindering precise localization of epileptic activity.
  • Dense array EEG employs significantly more electrodes (up to 256) to enhance spatial resolution.
  • Accurate localization of epileptiform discharges is crucial for understanding epilepsy and guiding treatment.

Purpose of the Study:

  • To investigate the utility of dense array EEG for cerebral cortical localization of epileptiform discharges.
  • To evaluate dense array EEG in long-term monitoring (LTM) for medically refractory epilepsy.
  • To compare dense array EEG findings with invasive LTM and surgical outcomes.

Main Methods:

  • Utilized dense array EEG with a realistic head tissue conductivity model and source analysis.
  • Applied dense array EEG for long-term EEG video monitoring in patients with refractory epilepsy.
  • Collected prospective data comparing dense array LTM with invasive LTM and surgical outcomes.

Main Results:

  • Dense array EEG successfully captured seizures in patients where standard LTM failed to provide reliable ictal localization.
  • Analysis suggests all seizures, including generalized types, propagate through distinct cortical networks.
  • Absence seizures show localized involvement of mesial and orbital frontal cortex.

Conclusions:

  • Dense array EEG demonstrates potential for noninvasive ictal localization, especially when standard methods are insufficient.
  • The technique may reduce the necessity for invasive EEG recordings.
  • Further research is needed to validate its role in guiding epilepsy treatment and device placement.