Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Auditory Pathway

Auditory Pathway

Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking the...

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

Seizures: Classification

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:

Motor and Sensory Areas of the Cortex

Motor and Sensory Areas of the Cortex

The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex.

Functional Brain Systems: Limbic System

Functional Brain Systems: Limbic System

The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...

Association Areas of the Cortex

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Prefrontal neuronal morphology in kindling-prone (FAST) and kindling-resistant (SLOW) rats.

Synapse (New York, N.Y.)·2021

Same author

Delayed myelination and neurodevelopment in male seizure-prone versus seizure-resistant rats.

Epilepsia·2018

Same author

Differences in white matter structure between seizure prone (FAST) and seizure resistant (SLOW) rat strains.

Neurobiology of disease·2017

Same author

Neuroanatomical differences in FAST and SLOW rat strains with differential vulnerability to kindling and behavioral comorbidities.

Epilepsy & behavior : E&B·2016

Same author

WONOEP appraisal: new genetic approaches to study epilepsy.

Epilepsia·2014

Same author

Studying autism in rodent models: reconciling endophenotypes with comorbidities.

Frontiers in human neuroscience·2013

Search research articles

Related Experiment Video

Updated: Jul 7, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

Mapping seizure pathways in the temporal lobe.

Dan C McIntyre¹, Krista L Gilby

¹Department of Psychology, Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada. Dan_McIntyre@carleton.ca

|May 28, 2008

Summary

This summary is machine-generated.

Animal models reveal consistent recruitment of parahippocampal cortices in temporal lobe seizures. These findings align with human temporal lobe epilepsy (TLE) studies, offering insights into seizure pathways.

More Related Videos

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

Related Experiment Videos

Last Updated: Jul 7, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

Area of Science:

Neuroscience
Epileptology

Background:

Temporal lobe epilepsy (TLE) has a long history, driving interest in its underlying pathways.
Recent research has focused on experimental animal models to understand TLE mechanisms.

Purpose of the Study:

To review network structures in the temporal lobe recruited during limbic seizures and status epilepticus in animal models.
To compare findings from animal models with human TLE studies.

Main Methods:

Review of existing literature on animal models of temporal lobe seizures.
Analysis of electrophysiological recordings (in vitro and in vivo).
Examination of molecular-level neuroplastic changes, energy utilization (14C2-deoxyglucose uptake), and behavioral consequences of network lesions.

Main Results:

Consistent recruitment of parahippocampal cortices (piriform, perirhinal, entorhinal areas) across various seizure models.
Evidence of cortical involvement demonstrated through electrophysiology, molecular changes, metabolic activity, and lesion studies.
Animal model conclusions closely mirror those from human TLE research.

Conclusions:

Parahippocampal cortical networks are critically involved in temporal lobe seizures across diverse animal models.
Animal models provide valuable insights that are highly relevant to understanding human temporal lobe epilepsy.
The study reinforces the historical understanding of TLE pathways, connecting past and present research.