Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intestinal permeability in piglets during transmissible gastroenteritis.

H J Egberts1, L Vellenga, J E van Dijk

  • 1Department of Veterinary Pathology, State University of Utrecht, The Netherlands.

Zentralblatt Fur Veterinarmedizin. Reihe A
|April 1, 1991
PubMed
Summary

Porcine transmissible gastroenteritis virus (TGE) infection in piglets increases small intestine permeability. This occurs alongside severe villous atrophy, impacting nutrient absorption and overall health.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microbial products from probiotic bacteria inhibit Salmonella enteritidis 857-induced IL-8 synthesis in Caco-2 cells.

Folia microbiologica·2010
Same author

Assessment of thyroid function in dogs with low plasma thyroxine concentration.

Journal of veterinary internal medicine·2007
Same author

Endocrine intervention during irradiation does not prevent damage to the thyroid gland.

Thyroid : official journal of the American Thyroid Association·2006
Same author

Indomethacin disrupts the protective effect of phosphatidylcholine against bile salt-induced ileal mucosa injury.

European journal of clinical investigation·2006
Same author

Partial purification and characterization of ferritin from the liver and intestinal mucosa of chickens, turtledoves and mynahs.

Avian pathology : journal of the W.V.P.A·2005
Same author

Expression of versican in relation to chondrogenesis-related extracellular matrix components in canine mammary tumors.

Histochemistry and cell biology·2005

Area of Science:

  • Veterinary Pathology
  • Gastroenterology
  • Virology

Background:

  • Porcine transmissible gastroenteritis virus (TGE) is a significant pathogen affecting swine.
  • TGE infection causes severe gastrointestinal distress, including diarrhea and appetite loss in piglets.
  • Understanding the impact of TGE on intestinal barrier function is crucial for disease management.

Purpose of the Study:

  • To investigate the effects of TGE virus infection on small intestinal macromolecular permeability in piglets.
  • To correlate changes in intestinal permeability with observed pathological alterations.

Main Methods:

  • Seven three-week-old piglets were infected with TGE-strain Miller.
  • Horseradish peroxidase (HRP) was administered intraluminally to assess macromolecular permeability.

Related Experiment Videos

  • Jejunal tissue samples were analyzed morphologically (stereomicroscopy, histology, ultrastructure) at 12 and 48 hours post-infection.

    • Main Results:

    • TGE-infected piglets exhibited loss of appetite and profuse diarrhea starting around 14 hours post-infection.
    • Increased horseradish peroxidase (HRP) permeability was observed in the jejunum of infected piglets at 48 hours post-inoculation.
    • Severe, hyper-regenerative villous atrophy was concurrently noted in TGE-infected piglets.

    Conclusions:

    • TGE virus infection significantly compromises the small intestinal barrier function in piglets.
    • The observed increase in macromolecular permeability is associated with severe villous atrophy.
    • These findings highlight the detrimental effects of TGE on intestinal integrity and function.