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Updated: Jul 7, 2026

Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Synthesis and biological evaluation of PEG-tirofiban conjugates
Laurent Désaubry1, Stéphanie Riché, Patricia Laeuffer
1UMR 7175 LC1, Université Louis Pasteur, CNRS, Faculté de Pharmacie, 67401 Illkirch, France. desaubry@chimie.u-strasbg.fr
Abstract:
We have conjugated tirofiban, an antagonist of the GPIIb/IIIa integrin receptor, to PEG, and shown that these polymers effectively inhibit platelet aggregation. This inhibition decreased with the size of the polymer. Our goal was to develop new cryoprotective agents to store frozen platelets. Surprisingly, tirofiban-conjugated PEG did not exhibit any protection.
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