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Furosemide and acute kidney injury in neonates
1Royal Victoria Infirmary, Newcastle upon Tyne, UK. nadeem.moghal@nuth.nhs.uk
Abstract:
Furosemide is a commonly used loop diuretic in neonatal intensive care. The common indications for the use of diuretics in neonates are fluid retention with adequate circulating blood volume, congestive heart failure, chronic lung disease (now rarely used) and acute kidney injury. This article discusses the pathophysiology of acute kidney injury in neonates and explores and maps the role of furosemide in this clinical situation. This is meant to be an easy to read, easy to digest, practical review for the jobbing clinician.
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Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
