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Published on: November 3, 2016
Cerebral palsy after perinatal arterial ischemic stroke
Meredith R Golomb1, Bhuwan P Garg, Chandan Saha
1Division of Pediatric Neurology, Indiana University School of Medicine, 575 West Drive, Indianapolis, IN 46202, USA. mgolomb@iupui.edu
Journal of Child Neurology
|February 29, 2008
Summary
Delayed presentation and male sex are key predictors of cerebral palsy in infants following perinatal arterial stroke. These findings help identify at-risk children for targeted interventions and care.
Area of Science:
- Neurology
- Pediatrics
- Developmental Neuroscience
Background:
- Perinatal arterial stroke is a significant cause of childhood neurological disability.
- Cerebral palsy (CP) is a common outcome, necessitating understanding of its predictors.
- Identifying risk factors aids in early intervention and management strategies.
Purpose of the Study:
- To determine the frequency and degree of disability in children with cerebral palsy following perinatal arterial stroke.
- To identify predictors of cerebral palsy in this population.
- To inform long-term rehabilitative care planning for affected children.
Main Methods:
- Analysis of a perinatal arterial stroke database including 111 children.
- Assessment of risk factors using univariate (Pearson chi(2), Fisher exact test) and multivariate (logistic regression) analyses.
- Evaluation of cerebral palsy occurrence, disability degree, and associated factors.
Main Results:
- Cerebral palsy was diagnosed in 68% of children with perinatal stroke, predominantly hemiplegic CP (87%).
- Multivariate analysis identified delayed presentation (OR, 9.96) and male sex (OR, 2.55) as significant predictors of CP.
- Subgroup analyses revealed associations between bilateral infarcts and severe CP, and unilateral middle cerebral artery infarcts with delayed presentation and large-branch infarction.
Conclusions:
- Delayed presentation and male sex are independently associated with an increased risk of cerebral palsy after perinatal stroke.
- Specific infarct patterns correlate with the severity of neurological impairment, guiding prognosis.
- These findings are crucial for physicians in developing tailored long-term care plans for children with perinatal stroke.
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