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[Target-controlled infusion (TCI): clinical tool or scientific toy?]

W Wilhelm1

  • 1Klinik für Anästhesiologie und operative Intensivmedizin, RTH Christoph 8, Klinikum St.-Marien-Hospital, 44534, Lünen. wolfram.wilhelm@smh-online.de

Der Anaesthesist
|February 29, 2008
PubMed
Abstract

No abstract available in PubMed .

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The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...