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Related Experiment Videos

Minimum detectable difference of MR diffusion maps in acute ischemic stroke.

Ashley D Harris1, Mirthula Govindaraj, Richard Frayne

  • 1Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region, Calgary, Alberta, Canada.

Journal of Magnetic Resonance Imaging : JMRI
|February 29, 2008
PubMed
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This study determined the minimum detectable difference (MDD) for apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in acute ischemic stroke. Results show that tissue type impacts analysis, while inter-observer reliability is a key concern for region-of-interest (ROI) analysis.

Area of Science:

  • Neuroimaging
  • Diffusion Tensor Imaging
  • Stroke Research

Background:

  • Region-of-interest (ROI) analysis is crucial for quantifying diffusion metrics in acute ischemic stroke.
  • Understanding the variability and minimum detectable difference (MDD) of these metrics is essential for reliable interpretation.
  • Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) are key diffusion tensor imaging (DTI) parameters.

Purpose of the Study:

  • To determine the minimum detectable difference (MDD) for ADC and FA in acute ischemic stroke.
  • To investigate the variability associated with ROI analysis of ADC and FA.
  • To compare the effects of different ROI types and tissue types (white matter vs. gray matter) on these metrics.

Main Methods:

  • Ten patients with acute ischemic stroke (<24 hours) underwent fast DTI.

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  • Four observers repeatedly drew two types of ROIs (free-hand polygon, ellipse) on ADC and FA maps in white and gray matter.
  • Analysis of variance (ANOVA) was used to assess tissue and ROI type effects, and inter/intra-observer variability.

    • Main Results:

    • MDD for ADC was 0.160 x 10(-3) mm(2)/s in white matter (WM) and 0.212 x 10(-3) mm(2)/s in gray matter (GM).
    • MDD for FA was 0.19 in WM and 0.10 in GM.
    • Tissue type significantly affected mean ADC and FA values, but ROI type did not. Intra-observer reliability was substantial; inter-observer reliability was poor-to-moderate.

    Conclusions:

    • MDD values for WM and GM in normal and ischemic tissues were established.
    • Inter- and intra-observer variability, along with tissue type, significantly influence the reliability of ROI analysis for ADC and FA in acute stroke.
    • These findings highlight the importance of standardized ROI placement and awareness of observer variability in DTI analysis of stroke.