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Updated: Jul 7, 2026
Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube
Published on: April 28, 2020
[Effect of Danxiongfang and its components on experimental liver injury models induced by CCl4 in mice]
Xiao-Rong Li1, Li-Juan Wang, Yu-Hang Li
1Department of Pharmacology, School of Chemical Biology and Pharmaceutical Sciences Institute of Material Medical, Capital Medical University, Beijing 100069, China.
Objective:
The study investigates the protective effect on liver of Danxionfang and its components.
Method:
Mice are injected with CCl4 to establish liver injured model. ALT, AST, serum albumin, globulin in serum and SOD, MDA in liver and liver histological changes were measured to confirm the ability of protecting liver of Danxiongfang.
Result:
The results show Danxiongfang can inhibit obviously the abnormal increase of ALT, AST in serum and MDA in liver, enhance SOD activity in liver, total protein, albumin, globulin in serum, and decrease liver pathological changes, which suggests Danxiongfang can protect injured liver induced by CCl4.
Conclusion:
Danxiongfang showed powerful protective effect against liver damage induced by CCl4.
