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Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Retroperitoneal fibroses: aetiopathogenesis and taxonomic assessment

C Alberti1

  • 1University of Parma, Parma, Italy.

European Review for Medical and Pharmacological Sciences
|March 1, 2008
PubMed

Insights

Retroperitoneal fibrosis (RPF) is a chronic inflammation that can entrap structures like ureters. Emerging evidence links idiopathic RPF to IgG4 autoimmune mechanisms, while secondary forms have diverse causes.

Area of Science:

  • Nephrology
  • Rheumatology
  • Pathology

Background:

  • Retroperitoneal fibrosis (RPF) is a chronic inflammatory condition affecting retroperitoneal structures.
  • Its etiology is diverse, including idiopathic, IgG4-related, and secondary causes like infections, drugs, and malignancies.
  • Understanding RPF's pathogenesis and classification is crucial for diagnosis and management.

Purpose of the Study:

  • To review the pathogenetic features of retroperitoneal fibrosis.
  • To discuss the taxonomic assessment of different RPF subtypes.
  • To highlight recent advances in diagnostic imaging and laboratory findings.

Main Methods:

  • Literature review focusing on pathogenetic mechanisms and classification of RPF.
  • Analysis of diagnostic imaging techniques (CT, MRI, PET/CT).
  • Evaluation of laboratory markers (CRP, ESR, IgG, IgG4, autoantibodies).

Main Results:

  • Idiopathic RPF is increasingly linked to IgG4-related mechanisms.
  • Secondary RPF encompasses causes such as atheromatous aortitis, drug-induced reactions, infections, and malignancies.
  • Advanced imaging and laboratory tests aid in identifying active inflammatory phases.

Conclusions:

  • RPF pathogenesis is complex, involving autoimmune and inflammatory pathways.
  • Accurate classification of RPF subtypes is essential for targeted treatment.
  • Multimodal diagnostic approaches improve the identification and characterization of RPF.

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