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Analysis of Cell Cycle Position in Mammalian Cells
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Alterations found in pl6/Rb/cyclin D1 pathway in the dysplastic and malignant cervical epithelium

N Vijayalakshmi1, G Selvaluxmi, U Majhi

  • 1Department of Molecular Oncology, Cancer Institute (WIA), Tamilnadu, India.

Oncology Research
|March 1, 2008
PubMed

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Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...