Related Experiment Video
Updated: Jul 7, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Nutrition transition and its relationship to the development of obesity and related chronic diseases
Arne Astrup1, Jørn Dyerberg, Matthew Selleck
1Department of Human Nutrition, Centre for Advanced Food Studies, Faculty of Life Sciences, The University of Copenhagen, Frederiksberg, Denmark. ast@life.ku.dk
Abstract:
The prevalence of overweight and obesity has also increased substantially in the nutritional transition countries, and the health burden of obesity-related complications is growing. The introduction of fast-food chains and Westernized dietary habits providing meals with fast-food characteristics seems to be a marker of the increasing prevalence of obesity. The mechanisms involved are probably that the supply of foods is characterized by large portion sizes with a high energy density, and sugar-rich soft drinks. The high energy density of foods is partly brought about by a high dietary fat content, and it has been shown that even in a Chinese population the increase from about 15% to 20% in the proportion of calories from fat is sufficient to explain some weight gain in the population. In addition, fast food from major chains in most countries still contains unacceptably high levels of industrially produced trans fatty acids that have powerful biological effects, and contribute to type 2 diabetes and coronary artery disease. New evidence also suggests that a high intake of trans fat may produce abdominal obesity, an important factor in the metabolic syndrome, type 2 diabetes and cardiovascular disease. The optimal diet for the prevention of weight gain, obesity, metabolic syndrome and type 2 diabetes is fat-reduced, without any industrially produced trans fatty acids, fibre-rich, high in low energy density carbohydrates (fruit, vegetables and whole grain products) and with a restricted intake of energy-containing drinks.
Related Concept Videos
Obesity
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
Type II Diabetes I: Introduction
Drug Dosing: Obese Patients
Regulation of Food Intake
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
