Related Experiment Video
Updated: Jul 7, 2026
09:04
Establishment and Maintenance of Patient-derived Prostate Cancer Organoids: A Detailed Experimental Protocol
Published on: November 14, 2025
[Pathologic characteristics of pseudohyperplastic prostatic adenocarcinoma]
Hui-zhen Zhang1, Zhi-ming Jiang, Lin Shi
1Department of Pathology, Shanghai Jiaotong University Affiliated Shanghai Sixth People's Hospital, Shanghai 200233, China.
Summary
Pseudohyperplastic prostatic adenocarcinoma (PHPA) is a common finding in prostate cancer, often co-occurring with conventional acinar adenocarcinoma. Despite its benign appearance, PHPA indicates moderately differentiated cancer with potential for metastasis.
Area of Science:
- Uropathology
- Oncology
- Cancer Research
Context:
- Pseudohyperplastic prostatic adenocarcinoma (PHPA) presents a diagnostic challenge due to its resemblance to benign prostatic glands.
- Understanding PHPA's clinicopathologic features is crucial for accurate diagnosis and patient management.
Purpose:
- To investigate the clinicopathologic characteristics of pseudohyperplastic prostatic adenocarcinoma (PHPA).
- To differentiate PHPA from well-differentiated adenocarcinoma and assess its association with conventional acinar adenocarcinoma.
Summary:
- PHPA was identified in 7% of needle biopsies and 15.2% of prostatectomy specimens, frequently co-existing with conventional acinar adenocarcinoma.
- Histologically, PHPA exhibits features mimicking benign glands but demonstrates malignant potential with stromal invasion in 66.7% of cases.
- Immunohistochemistry, including markers like 34betaE12, CK5/6, p63, and AMACR, aids in its diagnosis.
Impact:
- This study highlights that PHPA is not rare and signifies moderately differentiated prostate cancer (Gleason score 3), distinct from indolent forms.
- Accurate identification of PHPA is essential for appropriate staging and treatment planning in prostate cancer patients.
- Findings contribute to a better understanding of prostate cancer heterogeneity and its clinical implications.
Related Concept Videos
01:26Cellular Adaptation III: Hyperplasia
Hyperplasia is an increase in the number of cells in a tissue or organ due to enhanced cell division. It is an adaptive, controlled response to stimuli such as injury, hormones, or stress, involving mitosis to produce genetically identical cells and support tissue repair and regeneration.Tissue CapacityCertain tissues, including the epidermis, intestinal epithelium, bone marrow, and fibroblasts, have a high potential for hyperplasia. Others, such as bone, cartilage, and smooth muscle, show...
02:23Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
02:23Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:24Cellular Adaptation IV: Dysplasia and Metaplasia
DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...