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Updated: Jul 7, 2026

Two Peeling Methods for the Isolation of Photoreceptor Cell Compartments in the Mouse Retina for Protein Analysis
Published on: December 7, 2021
Dark and photoactivated rhodopsin share common binding modes to transducin
Francesca Fanelli1, Daniele Dell'orco
1Dulbecco Telethon Institute and Department of Chemistry, via Campi 183, 41100 Modena, Italy. fanelli@unimo.it <fanelli@unimo.it>
Abstract:
The structure of the photoactivated deprotonated rhodopsin intermediate was compared with two different structures of dark rhodopsin. Structure comparisons relied on the computation of molecular indices and on docking simulations with heterotrimeric transducin (Gt). The results of this study provide the first evidence that dark and photoactivated rhodopsins share a common recognition mode to Gt, characterized by the docking of the Gt alpha C-tail in the proximity to the E/DRY motif of rhodopsin.
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