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Left ventricular hypertrophy, compliance and ventricular filling
M Galderisi1, A Celentano, P Tammaro
1Department of Cardioangiology, Second Medical School, University of Naples, Italy.
The Journal of International Medical Research
|March 1, 1991
Summary
Hypertension with left ventricular hypertrophy (LVH) significantly impairs diastolic function, indicated by lower peak filling rates. Diastolic parameters effectively assess myocardial compliance and diastolic dysfunction in hypertensive patients.
Area of Science:
- Cardiology
- Hypertension Research
- Echocardiography
Background:
- Untreated hypertension can lead to left ventricular hypertrophy (LVH).
- LVH is associated with changes in cardiac structure and function.
- Assessing diastolic function is crucial in hypertensive patients.
Purpose of the Study:
- To investigate diastolic and systolic abnormalities in hypertensive patients with and without LVH.
- To determine the utility of diastolic parameters in assessing myocardial compliance.
Main Methods:
- Pulsed Doppler echocardiography and 99Tc radionuclide ventriculography were performed on 20 untreated hypertensive patients.
- Patients were divided into two groups based on mean diastolic wall thickness (MDWT > 1.2 cm) indicating LVH.
- Diastolic and systolic function indices were assessed at rest.
Main Results:
- Hypertensive patients with LVH exhibited significantly higher interventricular, posterior, and relative diastolic wall thickness (P < 0.01).
- Peak filling rate was significantly lower in hypertensives with LVH (P < 0.01).
- Systolic function indices did not differ significantly between groups.
Conclusions:
- Diastolic parameters, particularly peak filling rate, are sensitive markers of diastolic dysfunction in hypertension.
- These parameters may be valuable for evaluating myocardial compliance in hypertensive individuals with LVH.
- Diastolic dysfunction is a key consequence of LVH in hypertension.