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Blood Transfusion and Agglutination

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
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The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...

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Updated: Jul 7, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Development of a massive transfusion protocol.

Janis Bormanis¹

¹Ottawa Hospital, University of Ottawa, Canada. jbormanis@ottawahospital.on.ca

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis

|March 1, 2008

Summary

This summary is machine-generated.

Massive transfusion protocols manage uncontrolled bleeding, a critical issue in trauma and surgery. These evidence-based guidelines address the lethal triad of acidosis, hypothermia, and coagulopathy.

Related Experiment Videos

Last Updated: Jul 7, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Area of Science:

Emergency Medicine
Surgical Critical Care
Transfusion Medicine

Background:

Massive transfusion is a critical intervention for uncontrolled hemorrhage, commonly seen in trauma, cardiac, and vascular surgery.
It presents significant challenges to hospital resources and medical teams.
Established principles exist for managing massive transfusion, focusing on the "lethal triangle" of acidosis, hypothermia, and coagulopathy.

Purpose of the Study:

To present a protocol for managing massive transfusion.
To provide logical recommendations addressing the lethal triangle of acidosis, hypothermia, and coagulopathy.
To outline the integration of factor VIIa as an adjunct therapy.

Main Methods:

Protocol development involved multidisciplinary input from transfusion medicine, trauma surgery, emergency, ICU, and anesthesia specialists.
The protocol is distributed with the seventh unit of blood issued as a reminder of established principles.
Results associated with protocol implementation are tracked for potential modifications.

Main Results:

The protocol provides a structured approach to managing the physiological derangements associated with massive transfusion.
It integrates evidence-based recommendations for addressing acidosis, hypothermia, and coagulopathy.
The protocol facilitates the judicious use of adjunct therapies like factor VIIa.

Conclusions:

A standardized massive transfusion protocol can effectively guide management of severe hemorrhage.
Addressing the lethal triangle is paramount for improving outcomes in patients requiring massive transfusion.
Continuous monitoring and data tracking allow for protocol refinement and optimization.