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Cardiomyopathy III: Hypertrophic Cardiomyopathy

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Related Experiment Video

Updated: Jul 7, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

Hypertrophic cardiomyopathy.

Eveline F Yao¹

¹FAA Civil Aerospace Medical Institute, Oklahoma City, OK, USA.

Aviation, Space, and Environmental Medicine

|March 4, 2008

Summary

This summary is machine-generated.

Hypertrophic cardiomyopathy (HCM) is a heart condition causing left ventricular hypertrophy. Due to unpredictable risks, medical certification for pilots is generally denied.

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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

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Area of Science:

Cardiology
Aerospace Medicine

Background:

Hypertrophic cardiomyopathy (HCM) affects 1 in 500 individuals.
Characterized by inappropriate left ventricular hypertrophy without other causes.

Observation:

Sudden cardiac death (SCD) is a feared complication, sometimes the initial symptom.
HCM presents with significant heterogeneity and unpredictability.

Findings:

Risk stratification in HCM is challenging and imprecise.
Medical certification for pilots is restricted.

Implications:

Cases require FAA deferral for special issuance consideration.
First-class and full second-class medical certification are typically not permitted for individuals with HCM.