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Four-alpha-helix bundle with designed anesthetic binding pockets. Part II: halothane effects on structure and

Tanxing Cui1, Vasyl Bondarenko, Dejian Ma

  • 1Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA.

Biophysical Journal
|March 4, 2008
PubMed
Summary

Volatile anesthetics bind to a protein target, altering its structure and dynamics. This study reveals a novel induced-fit mechanism where halothane binding globally suppresses protein motion, potentially explaining anesthetic action.

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