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High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages
Published on: August 11, 2014
Identification of novel genes and pathways affecting Salmonella type III secretion system 1 using a contact-dependent
Terry R Field1, Abigail N Layton, Jennie Bispham
1Division of Microbiology, Institute for Animal Health, Compton, Berkshire, RG20 7NN, United Kingdom.
Journal of Bacteriology
|March 4, 2008
Abstract:
We screened 5,700 Salmonella enterica serovar Typhimurium mutants for defects in type III secretion system 1 (T3SS-1)-mediated contact-dependent hemolysis to identify novel genes and pathways affecting the activity of T3SS-1. Our data suggest that previously unrecognized factors such as type I fimbriae may modulate the expression, activity, or deployment of this key virulence factor.
