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Altered CSF 5-HIAA Disposition in Pathologic Male Gamblers.

C Nordin¹, T Eklundh

¹Department of Neuroscience and Locomotion, Division of Psychiatry, University Hospital, Linköping, Sweden.

|March 4, 2008

Summary

Pathologic gamblers show lower levels of cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) and 4-hydroxy-3-methoxyphenyl glycol (HMPG), suggesting altered serotonin and norepinephrine function.

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Area of Science:

Neuroscience
Biochemistry
Psychiatry

Background:

Previous studies indicated disturbed norepinephrine and dopamine function in pathologic gamblers' cerebrospinal fluid (CSF).
Serotonin system functioning in pathologic gambling has remained less understood.

Purpose of the Study:

To investigate neurotransmitter metabolite levels in the CSF of pathologic gamblers.
To compare CSF neurotransmitter metabolite profiles between pathologic gamblers and healthy controls.

Main Methods:

Analyzed two CSF samples from 10 male pathologic gamblers and healthy male controls.
Measured concentrations of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 4-hydroxy-3-methoxyphenyl glycol (HMPG).
Accounted for CSF mass flow rate (tapping time) for concentration calculations.

Main Results:

CSF 5-HIAA and HMPG levels, adjusted for tapping time, were significantly lower in gamblers compared to controls.
CSF HVA levels did not differ significantly between groups when adjusted for tapping time.
A significant correlation between 5-HIAA and HVA was observed in gamblers, but not in controls.

Conclusions:

Altered indolamine (serotonin precursor) function in pathologic gamblers cannot be ruled out, despite previous findings focused on norepinephrine and dopamine.
Findings suggest potential dysregulation in serotonin pathways contributing to pathologic gambling behavior.