Measurement of the hemoglobin oxygen saturation level with spectroscopic spectral-domain optical coherence tomography
Chih-Wei Lu1, Cheng-Kuang Lee, Meng-Tsan Tsai
1Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, Taiwan.
Abstract:
We report the measurement of the hemoglobin (Hb) oxygen saturation level in human blood with a spectroscopic spectral-domain optical coherence tomography (SSD-OCT) system based on the crossover behavior of Hb and oxyhemoglobin (HbO(2)) absorption coefficients around 800 nm. By calculating the ratio of the exponential decay constant of A-mode scan signal in the long-wavelength range (>800 nm) over that in the short-wavelength range (<800 nm), the relative oxygen saturation level of Hb can be calibrated. Such a relative level can be used for practical diagnosis application after a golden standard is built by comparing the variation of the OCT result with that of a conventional method, such as the use of a blood gas analyzer. In our experiment, the variation curve based on the SSD-OCT measurement, which has the advantages of noninvasive, real-time, and high-resolution measurements, is coincident with that of using a commercial blood gas analyzer.
Related Concept Videos
Special considerations while measuring oxygen saturation
Ensuring accuracy in vital sign recordings while prioritizing patient comfort and minimizing anxiety is important.
Guidelines For Measuring Vital Signs
Before taking a patient's vital signs, a nurse would consider and assess the patient's comfort level and ensure appropriate equipment is available.
Pulse Oximetry
Purpose
Average SpO2 values are greater than 95%. If the readings fall below 90%, it indicates that...
Assessment of Diffusion and Perfusion
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...
Oxygen Transport in the Blood
Spectrophotometry: Introduction
The essential components of a spectrophotometer include a source of electromagnetic radiation, a slot for placing a material to be analyzed, and a...


