Principles and recent advances in human DNA fingerprinting
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A J Jeffreys1, N J Royle, I Patel
1Department of Genetics, University of Leicester, Great Britain.
EXS
|January 1, 1991
Abstract:
Since 1985, DNA typing systems have played an increasingly important role in many aspects of human genetics, most notably in forensic and legal medicine. This article reviews the development of multilocus and single locus minisatellite DNA probes, and more recently the use of PCR to amplify hypervariable DNA loci, as well as discussing the biological properties of the unstable regions of DNA which form the basis of almost all DNA fingerprinting systems.