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Updated: Jul 7, 2026
06:38
An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
Hepatocellular carcinoma (HCC): current and evolving therapies.
1Departments of Medicine and Transplantation, Division of Hepatology and Complex GI, Physicians Foundation, California Pacific Medical Center, PO Box 7999, San Francisco, CA 94115-7999, USA, gishr@sutterhealth.org
Idrugs : the Investigational Drugs Journal
|March 4, 2008
Summary
Hepatocellular carcinoma (HCC) survival rates are low, with rising incidence. New treatments like kinase inhibitors and immunotherapy offer hope beyond surgery and transplantation.
Area of Science:
- Hepatology and Oncology
- Cancer Therapeutics
Background:
- Hepatocellular carcinoma (HCC) presents a significant global health challenge with historically poor 5-year survival rates.
- The incidence of HCC is increasing in many regions, including the United States, necessitating urgent advancements in treatment.
- Current curative treatments like surgical resection and liver transplantation are limited to a select patient population.
Purpose of the Study:
- To review current and emerging therapeutic strategies for Hepatocellular Carcinoma (HCC).
- To highlight the limitations of existing treatments and the need for novel approaches.
Main Methods:
- Review of existing literature on HCC treatment modalities.
- Discussion of established curative and non-curative therapies.
- Exploration of novel and investigational treatments, including targeted therapies and immunotherapies.
Main Results:
- Curative options for HCC include surgery, transplantation, and ablative therapies, each with specific patient criteria.
- Non-curative options for advanced HCC involve transarterial embolization and radiation-based therapies.
- Emerging treatments encompass Raf kinase inhibitors (e.g., sorafenib), immunotherapy, and tyrosine kinase inhibitors.
Conclusions:
- There is a critical unmet need for expanded treatment options for Hepatocellular Carcinoma.
- Ongoing research into novel therapeutic approaches, including targeted therapies and immunotherapies, holds promise for improving HCC patient outcomes.
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