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Related Experiment Video

Updated: Jul 7, 2026

Rodent Stereotaxic Surgery and Animal Welfare Outcome Improvements for Behavioral Neuroscience

Rodent Stereotaxic Surgery and Animal Welfare Outcome Improvements for Behavioral Neuroscience

Published on: January 30, 2012

A stereotactic device for rabbits based on mandibular and cranial landmarks: technical note.

Ralf A Kockro¹, Rainer Giacomelli, Martin Scheihing

¹Department of Neurosurgery, University of Mainz, Germany. rkockro@volumeinteractions.com

Journal of Neurosurgery

|March 4, 2008

Summary

Researchers developed a novel stereotactic device for rabbits, achieving high accuracy for reproducible ventricular catheter implantation. This cost-effective tool enhances surgical precision in preclinical studies.

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Adaptable Angled Stereotactic Approach for Versatile Neuroscience Techniques

Adaptable Angled Stereotactic Approach for Versatile Neuroscience Techniques

Published on: May 7, 2020

Area of Science:

Neurosurgery
Medical Devices
Preclinical Research

Background:

Developing accurate stereotactic methods is crucial for reproducible neurosurgical procedures in animal models.
Existing stereotactic devices may lack the necessary precision or cost-effectiveness for large-scale preclinical studies.

Purpose of the Study:

To develop and validate a novel, cost-effective stereotactic device for rabbits.
To achieve reproducible trajectory accuracy for lateral ventricle catheter implantation.

Main Methods:

A stainless steel stereotactic device was designed using the mandibular plane and cranial sutures as anatomical references.
Sixty rabbits underwent stereotactic surgery for catheter implantation.
Postmortem dissections were performed to assess trajectory accuracy.

Main Results:

The stereotactic device demonstrated high accuracy, with 78.6% of trajectories within a 5-degree deviation and 94.6% within 10 degrees.
The last 18 consecutively operated animals achieved consistent accuracy within a 5-degree tolerance.
The device is autoclavable, simple, inexpensive, and allows for rapid, sterile procedures.

Conclusions:

The developed stereotactic device provides accurate and reproducible guidance for ventricular punctures in rabbits.
Its cost-effectiveness and ease of use make it suitable for preclinical research requiring "approximate" stereotactic guidance, especially for high-throughput studies.