Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A new in vitro method to predict in vivo photoprotection of skin hyperpigmentation induced by visible light.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022

Same author

Non-invasive profiling for cytokines, chemokines and growth factors in acne vulgaris.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019

Same author

Vasoconstrictor potency of fixed-dose combination calcipotriol (50 μg/g) and betamethasone dipropionate (0.5 mg/g) cutaneous foam versus other topical corticosteroids used to treat psoriasis vulgaris.

The Journal of dermatological treatment·2018

Same author

Noninvasive proteome analysis of psoriatic stratum corneum reflects pathophysiological pathways and is useful for drug profiling.

The British journal of dermatology·2017

Same author

Echographic assessment of corticosteroid-induced skin-thinning, including echogenicity measurement.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2016

Same author

Enhanced vasoconstrictor potency of the fixed combination calcipotriol plus betamethasone dipropionate in an innovative aerosol foam formulation vs. other corticosteroid psoriasis treatments.

Journal of the European Academy of Dermatology and Venereology : JEADV·2016

Search research articles

Related Experiment Video

Updated: Jul 7, 2026

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

Cellulite and skin ageing: is there any interaction?

J P Ortonne¹, M Zartarian, M Verschoore

¹Dermatology Department, Archet Hospital, Nice, France. beni.amatya@ki.se

Journal of the European Academy of Dermatology and Venereology : JEADV

|March 4, 2008

Summary

Cellulite in women accelerates skin aging, with altered skin properties appearing earlier in those with cellulite compared to controls. Early intervention may prevent premature skin aging associated with cellulite.

Related Experiment Videos

Last Updated: Jul 7, 2026

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

Area of Science:

Dermatology
Aesthetics
Aging Research

Background:

Cellulite is a common concern affecting women's skin appearance.
The relationship between cellulite and the skin aging process requires further investigation.

Purpose of the Study:

To characterize cellulite in women across different age groups.
To determine if cellulite influences skin aging.

Main Methods:

Non-invasive techniques were used on 94 healthy females across three age groups (21-30, 31-40, 51-60) and two cellulite grades (grade 2 and grade 0/control).
Quantified cellulite's 'orange peel appearance' by measuring shadowed surfaces.
Assessed biomechanical properties (extensibility, retractability, elasticity), skin thickness via ultrasound, dermis echogenicity, and density.

Main Results:

Cellulite (grade 2) showed age-dependent changes in shadowed surface characteristics, becoming smaller and more numerous after age 30.
Total skin and hypodermis thickness increased by approximately 30% in the cellulite group compared to controls, regardless of age.
Biomechanical properties and dermis echogenicity were significantly altered earlier (from age 30) in the cellulite group compared to the control group (from age 50).

Conclusions:

Women with cellulite exhibit earlier signs of skin aging than those without.
Two distinct cellulite sub-populations were identified: under 30 with large dimples and normal properties, and over 30 with smaller dimples and altered dermis.
Preventing premature skin aging associated with cellulite is recommended.