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Published on: June 20, 2025
Interleukin-6 and soluble intercellular adhesion molecule-1 in acute brain ischaemia
D Orion1, Y Schwammenthal, T Reshef
1Stroke Center, Department of Neurology and Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Israel.
European Journal of Neurology
|March 4, 2008
Summary
High interleukin-6 (IL-6) levels correlate with stroke severity and poorer outcomes in acute brain ischemia patients. However, IL-6 does not offer additional prognostic value beyond initial stroke severity assessment.
Area of Science:
- Biomedical Science
- Neuroscience
- Cardiovascular Research
Background:
- Inflammation is a key factor in atherothrombosis.
- Understanding inflammatory markers in acute brain ischemia is crucial for prognosis.
Purpose of the Study:
- To investigate the association between plasma inflammatory biomarkers and the severity and outcome of acute brain ischemia.
- To evaluate the prognostic value of interleukin-6 (IL-6) and soluble intercellular adhesion molecule-1 (sICAM-1) in stroke patients.
Main Methods:
- Plasma samples from 113 acute brain ischemia patients were analyzed for IL-6 and sICAM-1 concentrations using ELISA.
- Stroke severity was assessed using the National Institute of Health stroke scale.
- Patient outcomes were evaluated using the modified Rankin Scale (mRS) and Stroke Impact Scale-16 (SIS).
Main Results:
- Elevated IL-6 concentrations, but not sICAM-1, were significantly associated with stroke severity (P < 0.01).
- Higher IL-6 levels correlated with increased disability (mRS ≥ 2) and poorer physical function (SIS ≤ 85).
- These associations were no longer significant after adjusting for baseline stroke severity.
Conclusions:
- Plasma IL-6 levels are associated with the severity of acute brain ischemia.
- While IL-6 reflects stroke severity, it does not provide additional prognostic information for patient outcomes beyond initial severity assessment.
- sICAM-1 did not show a significant association with stroke severity or outcome in this cohort.
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