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Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
Published on: June 13, 2018
Cutaneous infection with an Alternaria sp. in an immunocompetent host
C Williams1, A M Layton, K Kerr
1Department of Dermatology, Harrogate District Hospital, Harrogate, UK. tinawilliams@doctors.org.uk
Clinical and Experimental Dermatology
|March 4, 2008
Abstract:
We report a case of cutaneous alternariosis in an immunocompetent 85-year-old man. Identification of the causative organism in this patient was achieved by 18S rRNA sequencing. A 6-month course of itraconazole led to a good clinical response.
Insights
This study details a rare case of cutaneous alternariosis in an 85-year-old man. Treatment with itraconazole for six months resulted in a positive clinical outcome.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Dermatology
Background:
- Cutaneous alternariosis is a fungal infection typically affecting the skin.
- While often associated with immunocompromised individuals, rare cases occur in immunocompetent hosts.
Observation:
- An 85-year-old immunocompetent male presented with cutaneous alternariosis.
- The causative fungal species was identified using 18S rRNA gene sequencing.
Findings:
- Successful identification of the etiological agent of cutaneous alternariosis.
- A six-month treatment course of itraconazole demonstrated significant clinical efficacy.
Implications:
- Highlights the potential for Alternaria species to cause infection in immunocompetent individuals.
- Suggests itraconazole as an effective therapeutic option for cutaneous alternariosis.
- Emphasizes the utility of molecular methods like 18S rRNA sequencing for accurate fungal identification.
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