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Updated: Jul 7, 2026
Laparoscopic Extracorporeal Knot-Tying for Uterine Vessel Occlusion during Hysterectomy with Cervical Cerclage in Large Uteri
Published on: September 12, 2025
Intramyometrial injection of vasopressin in laparoscopic supracervical hysterectomy
Ali Ghomi1, Fadi Makhlouf, Seshadri Kasturi
1Department of Gynecology-Obstetrics, University at Buffalo, The State University of New York, Buffalo, New York 14222, USA. alighomi@buffalo.edu
Study Objective:
To investigate the effectiveness of vasopressin in reducing blood loss in laparoscopic supracervical hysterectomy (LSH).
Design:
Retrospective chart analysis (Canadian Task Force classification II-2).
Setting:
University-affiliated teaching hospital.
Patients:
In all, 143 women who had LSH for benign gynecologic disease.
Interventions:
Laparoscopic supracervical hysterectomy.
Measurements And Main Results:
From January 2001 through December 2006, 143 patients were identified who had consecutive, successful LSH performed by different gynecologic laparoscopists. There were no exclusion criteria. The patients were divided into 2 groups based on whether intramyometrial vasopressin injection was used intraoperatively to reduce blood loss; 77 (54%) patients received intramyometrial vasopressin injection and 66 (46%) did not. The 2 groups were compared with regard to blood loss, operating time, uterine weight, hospital stay, concomitant salpingo-oophorectomy, perioperative complications, and patient characteristics including age, gravity, parity, body mass index, surgical history, and number of cesarean deliveries. No difference existed in the first postoperative day decrease in hemoglobin between the vasopressin and control group (2.3 +/- 0.9 vs 2.1 +/- 1.2 g/dL, respectively, p = .56). No significant difference existed between the groups with respect to operating time (146.9 +/- 52.6 vs 131.9 +/- 42.8 min, p = .07) or uterine weight (145.4 +/- 121.8 vs 119.5 +/- 66.9 g, p = .14). All other parameters and patient characteristics were similar between the 2 groups except for the duration of hospital stay. Patients who received intramyometrial vasopressin injection experienced a slightly longer duration of hospital stay (1.4 +/- 0.7 vs 1.1 +/- 0.4 days, p = .02).
Conclusion:
Our study does not support the routine use of intramyometrial vasopressin injection during LSH to reduce blood loss.
