Related Experiment Video
Updated: Jul 7, 2026
07:42
An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents
Published on: August 2, 2018
Integrating hippocampus and striatum in decision-making
Adam Johnson1, Matthijs A A van der Meer, A David Redish
1University of Minnesota, Neuroscience, Minneapolis, MN 55455, United States.
Current Opinion in Neurobiology
|March 4, 2008
Summary
Flexible decision-making involves the hippocampus and striatum, integrating planning with cached values. Recent findings show hippocampal forward-shifted representations guiding downstream evaluation for adaptive behavior.
Area of Science:
- Neuroscience
- Cognitive Science
- Decision-Making Research
Background:
- Decision-making literature highlights interactions between flexible, planning-based systems and rigid, cached-value systems.
- Flexible decision-making models incorporate prospection and projection, often involving the hippocampus.
Purpose of the Study:
- To explore the neural mechanisms underlying flexible and stimulus-response decision-making.
- To investigate the role of the hippocampus and striatum in integrating different memory systems for adaptive behavior.
Main Methods:
- Analysis of recent recordings from rodent hippocampus during decision-making tasks.
- Review of existing literature on neural correlates of decision-making and memory systems.
Main Results:
- Transient forward-shifted representations were observed in the rodent hippocampus during decision-making.
- Evidence suggests the striatum plays a dual role, supporting both flexible (ventral and dorsomedial striatum) and stimulus-response (dorsolateral striatum) strategies.
Conclusions:
- The hippocampus generates predictive representations, with downstream areas like the orbitofrontal cortex and striatum evaluating these predictions for action selection.
- The striatum is implicated in both goal-directed and stimulus-response decision-making, challenging its classical view as solely part of a rigid system.
More Related Videos
07:05Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents
Published on: September 10, 2018
05:48The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
Published on: June 12, 2020
Related Concept Videos
01:19Role of Hippocampus in Memory
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
01:37Reason and Intuition
The human brain processes information for decision-making using one of two routes: an intuitive system and a rational system (Epstein, 1994; popularized by Kahneman, 2011 as System 1 and System 2, respectively). The intuitive system is quick, impulsive, and operates with minimal effort, relying on emotions or habits to provide cues for what to do next, while the rational system is logical, analytical, deliberate, and methodical. Research in neuropsychology suggests that the brain can only use...
01:15Functional Brain Systems: Limbic System
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
01:20Decision Making
Decision-making is a fundamental cognitive process that involves evaluating alternatives and selecting among them. This process can range from simple choices, such as deciding what to wear, to complex decisions, like choosing a major in college or a career path. The complexity of the decision often dictates the approach we use, which can be broadly categorized into two types: automatic and controlled decision-making.
Automatic decision-making is fast, intuitive, and relies on gut feelings...
Automatic decision-making is fast, intuitive, and relies on gut feelings...
01:14Role of Cerebellum and Prefrontal Cortex in Memory
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the cerebellum's...
01:25Olfaction
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...