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Related Experiment Video

Updated: Jul 7, 2026

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Published on: March 20, 2017

Obesity and impaired venous function.

A M van Rij¹, C S De Alwis, P Jiang

¹Department of Surgery, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand. andre.vanrij@stonebow.otago.ac.nz

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery

|March 4, 2008

Summary

This summary is machine-generated.

Obese patients exhibit more severe venous disease, with worse venous reflux but better muscle pump function compared to normal-weight individuals. Increased weight correlates with higher venous pressures and larger superficial femoral vein diameter.

Related Experiment Videos

Last Updated: Jul 7, 2026

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Published on: March 20, 2017

Area of Science:

Vascular Medicine
Phlebology
Obesity Medicine

Background:

Clinical severity of venous disease is often exacerbated in obese patients.
Understanding the impact of obesity on lower limb venous physiology is crucial for effective management.

Purpose of the Study:

To compare lower limb venous physiology between obese and normal-weight patients using air plethysmography.
To evaluate the influence of posture on venous measures and foot vein pressure in a cohort with varying body weights.

Main Methods:

Air plethysmography and duplex scanning assessed venous function in 934 patients (obese vs. non-obese).
A subgroup of 20 patients had foot vein pressures and femoral vein diameter measured in different postures (standing, sitting, lying, ambulating).

Main Results:

Obese patients presented with more advanced clinical venous disease (CEAP C5&6: 35.4% vs. 20.5%).
Obesity was associated with worse venous reflux but improved muscle pump function and reduced residual volumes.
Higher body weight correlated with increased superficial femoral vein diameter, ambulatory venous pressure, venous filling index, and ejection volume, with greater foot venous pressure in obese individuals.

Conclusions:

Obese patients demonstrate a more advanced clinical stage (CEAP) of venous disease compared to non-obese individuals with similar anatomical patterns of venous incompetence.
Elevated intra-abdominal pressure in obese individuals may contribute to increased venous reflux, vein diameter, and pressures.