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Related Concept Videos

Types of Reversible Electrodes01:24

Types of Reversible Electrodes

For electrode reversibility to be maintained, all the reactants and products involved in the half-reaction must be present at the electrode. There are several types of reversible electrodes (half-cells).In metal-metal-ion electrodes, a metal balances electrochemically with a solution of its own ions. Examples are Cu2+|Cu and Zn2+|Zn. Metals that react with the solvent, like group 1 and most group 2 metals, which react with water, and zinc, which reacts with aqueous acidic solutions, cannot be...

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Conformable Wearable Electrodes: From Fabrication to Electrophysiological Assessment
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Published on: July 22, 2022

Versatile bioelectronic interfaces on flexible non-conductive substrates.

Brian L Hassler1, Ted J Amundsen, J Gregory Zeikus

  • 1Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824, United States.

Biosensors & Bioelectronics
|March 4, 2008
PubMed
Summary

A novel bench-top method creates versatile bioelectronic interfaces on nonconductive materials for biosensors. This approach utilizes layer-by-layer deposition and self-assembly, enabling flexible and cost-effective applications.

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Bridging the Bio-Electronic Interface with Biofabrication
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Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

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Bridging the Bio-Electronic Interface with Biofabrication
16:38

Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

Area of Science:

  • Electrochemistry
  • Materials Science
  • Biotechnology

Background:

  • Bioelectronic interfaces enable electrical communication between enzymes and electrodes for biosensors and biofuel cells.
  • Traditional methods like PVD and CVD for gold film deposition are substrate-limited and require expensive equipment.
  • A need exists for versatile, cost-effective methods to create bioelectronic interfaces on diverse substrates.

Purpose of the Study:

  • To develop a versatile bench-top method for creating bioelectronic interfaces on nonconductive substrates.
  • To incorporate gold films, electron mediators, cofactors, and dehydrogenase enzymes into the interfaces.
  • To demonstrate the applicability of these interfaces on flexible and inexpensive materials.

Main Methods:

  • Layer-by-layer deposition of polyelectrolytes.
  • Electroless metal deposition for gold film formation.
  • Directed molecular self-assembly for enzyme integration.
  • Characterization using cyclic voltammetry, chronoamperometry, and microscopy techniques.

Main Results:

  • Successful formation of bioelectronic interfaces containing gold, mediators, cofactors, and enzymes (secondary alcohol dehydrogenase, sorbitol dehydrogenase) on polystyrene and glass.
  • Demonstrated electrical communication between enzymes and electrodes.
  • Interfaces on flexible polystyrene retained activity after bending, indicating robustness.

Conclusions:

  • The developed method offers a versatile and cost-effective approach for creating bioelectronic interfaces on nonconductive substrates.
  • This technique is suitable for flexible electronics and applications where traditional methods are not feasible.
  • Potential applications include personal health monitors, structural health monitors, and rolled microtube biosensors.