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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

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Related Experiment Video

Updated: Jul 7, 2026

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

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Proteomics: methodologies and applications in oncology.

Bradly G Wouters¹

¹Department of Radiation Oncology (Maastro Lab), GROW Research Institute, Maastricht University, Maastricht, The Netherlands. brad.wouters@maastro.unimaas.nl

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Summary

Proteomics, the study of proteins, offers potential for clinical diagnostics. Advances in mass spectrometry and bioinformatics accelerate protein discovery for patient care, especially in radiotherapy.

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Area of Science:

Biochemistry
Molecular Biology
Clinical Diagnostics

Background:

Proteomics investigates all cellular proteins, reflecting gene regulation's end result.
The proteome, though complex, is finite, with ongoing acceleration in protein discovery.
Technological advancements are crucial for proteomics' clinical integration.

Purpose of the Study:

To review current proteomic technologies.
To discuss the transition of proteomics from discovery to systematic profiling.
To highlight efforts in applying proteomics to clinical settings, particularly in radiotherapy.

Main Methods:

Mass spectrometry-based technologies
Genomic databases
Bioinformatic tools

Main Results:

Accelerated rate of protein discovery.
Potential for systematic proteome profiling.
Emerging clinical applications in patient diagnostics and prognostics.

Conclusions:

Proteomics holds significant promise for revolutionizing clinical diagnostics and prognostics.
Technological improvements are driving proteomics towards clinical utility.
The field is shifting towards systematic profiling for broader patient benefit.