Pyoderma gangrenosum of the penis: a potentially dramatic skin disease

We report the case of a 17-year-old boy who presented with penile ulceration and a urethral fistula that had failed to heal after plastic reconstructions with skin grafts. The patient had a history of pathergy, because the initial lesion was an ulcer that deteriorated and led to the development of the fistula after surgical interventions for its repair. On the basis of the patient's history and normal laboratory evaluation findings, the diagnosis of penile pyoderma gangrenosum was made, and the patient began corticosteroids and cyclosporine. Four months after treatment initiation, the penile area was free of inflammation and ulceration.