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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Production of Formed Elements01:34

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...

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Related Experiment Video

Updated: Jul 7, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
08:43

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Endothelial progenitor cells and rheumatic disorders.

Jérôme Avouac1, Georges Uzan, André Kahan

  • 1Rheumatology A department, René Descartes University, Cochin Hospital, APHP, 27 rue du faubourg Saint-Jacques, 75014 Paris, France.

Joint Bone Spine
|March 4, 2008
PubMed
Summary

Endothelial progenitor cells (EPCs) are key to forming new blood vessels. Research explores their role in rheumatic diseases, suggesting they may serve as biomarkers and influence disease progression and cardiovascular risks.

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Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood
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Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood
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Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

Published on: April 13, 2012

Related Experiment Videos

Last Updated: Jul 7, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
08:43

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood
07:26

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Published on: September 14, 2017

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood
13:46

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

Published on: April 13, 2012

Area of Science:

  • Cardiovascular Biology
  • Rheumatology
  • Cell Biology

Background:

  • New blood vessel formation occurs via angiogenesis or vasculogenesis.
  • Endothelial progenitor cells (EPCs) are bone marrow-derived cells crucial for vasculogenesis.
  • The precise role and quantification of EPCs in human health and disease remain under investigation.

Purpose of the Study:

  • To explore the role of EPCs in the context of rheumatology.
  • To investigate EPCs as potential biomarkers in multiple myeloma and inflammatory rheumatic disorders.
  • To understand EPC involvement in synovial vascularization and cardiovascular complications in rheumatoid arthritis.

Main Methods:

  • Review of existing literature on EPCs in rheumatology.
  • Analysis of data from studies on multiple myeloma, rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis.
  • Exploration of EPC mobilization, homing, and differentiation processes.

Main Results:

  • EPCs show potential as biomarkers for tumor angiogenesis and antiangiogenic therapy efficacy in myeloma.
  • EPCs are implicated in synovial vascularization and cardiovascular morbidity in rheumatoid arthritis.
  • EPC levels appear decreased in systemic lupus erythematosus and may be depleted in later stages of systemic sclerosis.

Conclusions:

  • EPCs play a significant role in vasculogenesis and may be involved in systemic features of inflammatory rheumatic disorders.
  • Further research is needed to clarify EPC phenotype, mobilization, homing, and quantification methods.
  • EPCs represent a promising area for understanding and potentially treating rheumatic diseases and associated complications.