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Comparative Lesions Analysis Through a Targeted Sequencing Approach

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

Detecting Lynch syndrome by pathologists.

J H van Krieken¹, C M Kets, M J Ligtenberg

¹Department for Pathology, Radboud University Nijmegen Medical Centre.

Verhandlungen Der Deutschen Gesellschaft Fur Pathologie

|March 5, 2008

Summary

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Determinants of adherence to recommendations on physical activity, red and processed meat intake, and body weight among lynch syndrome patients.

Familial cancer·2022

Lynch syndrome, a hereditary condition, significantly increases colorectal cancer risk. Pathologists can identify potential cases using clinical and pathological features, enabling timely screening for affected families.

Area of Science:

Oncology
Genetics
Pathology

Background:

Lynch syndrome, previously known as hereditary nonpolyposis colorectal cancer, is an inherited condition associated with a high risk of early-onset colorectal cancer.
Approximately 2-3% of all colorectal cancers are linked to Lynch syndrome, characterized by microsatellite instability (MSI) due to mismatch repair gene mutations.

Purpose of the Study:

To propose a cost-effective and ethically sound method for pathologists to detect Lynch syndrome.
To improve the recognition of Lynch syndrome in colorectal cancer cases.

Main Methods:

Utilizing clinical indicators such as colorectal cancer in patients under 50 or multiple colorectal cancers in one individual.
Employing pathological features like mucinous carcinoma and intraepithelial lymphocytes for identification.

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Comparative Lesions Analysis Through a Targeted Sequencing Approach

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Published on: January 9, 2019

Main Results:

Pathologists are increasingly capable of recognizing colorectal cancers associated with Lynch syndrome based on specific features.
The proposed approach aims to enhance the detection rate of Lynch syndrome in clinical practice.

Conclusions:

Early and accurate identification of Lynch syndrome is crucial for implementing necessary screening programs for patients and their families.
Pathologist-driven detection offers a practical strategy for identifying Lynch syndrome.