Related Experiment Video
Updated: Jul 7, 2026

Analysis of the Expression and Complexes Assembly of the Mitochondrial Respiratory Chain Proteins in the Fission Yeast Schizosaccharomyces pombe
Published on: May 2, 2025
Neurospora crassa as a model organism for mitochondrial biogenesis
Frank E Nargang1, Doron Rapaport
1Department of Biological Sciences, University of Alberta, Edmonton, Canada.
Abstract:
Neurospora crassa has proven to be an excellent organism for studying various aspects of the biology of mitochondria by biochemical and genetic approaches. As N. crassa is an obligate aerobe and contains complex I, its mitochondria are more similar to mammalian mitochondria than those of yeast. The recent sequencing of the genome of N. crassa and a gene knockout project that is under way make the organism even more attractive. We describe some of the advantages of N. crassa as a model organism and present methods for isolation of mitochondria, fractionation of these organelles, and disruption of essential genes in this organism.
Related Concept Videos
Mitochondrial Precursor Proteins
Most of the mitochondrial precursors...
Mitochondria
Mitochondria
Mitochondrial Membranes
Mitochondrial Membranes
