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Updated: Jul 7, 2026

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
Synthesis of multifunctional polyvinylsaccharide containing controllable amounts of biospecific ligands
V Korzhikov1, S Roeker, E Vlakh
1Institute of Macromolecular Compounds, Russian Academy of Science, Bolshoy pr. 31, 199004, St. Petersburg, Russia.
Abstract:
In the present study, the attempt to synthesize a multibiofunctional polymeric vector to be used for construction of composite scaffolds for bone tissue engineering has been undertaken. The polymers based on 2-deoxy-2-methacrylamido- d-glucose were functionalized by a growth factor (BMP-2), GRGDSP peptide, and poly( l-lysine) using aldehyde chemistry. The covalent modification process was quantitatively studied, and a polymer conjugate containing all these ligands was formed. In addition, the impacts of coupled ligands toward the adsorption of polymers on the commercial mineral macroporous matrix Sponceram used in cell culture applications were studied.
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