Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Atomic Force Microscopy

Atomic Force Microscopy

Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Acoustic streaming enhances the Multicyclic CO2 capture of natural limestone at Ca-looping conditions.

Environmental science & technology·2013

Same author

Improving the gas-solids contact efficiency in a fluidized bed of CO2 adsorbent fine particles.

Physical chemistry chemical physics : PCCP·2011

Same author

Magnetic field induced inversion in the effect of particle size on powder cohesiveness.

The Journal of chemical physics·2010

Same author

Pull-off force of coated fine powders under small consolidation.

Physical review. E, Statistical, nonlinear, and soft matter physics·2009

Same author

Magnetofluidization of fine magnetite powder.

Physical review. E, Statistical, nonlinear, and soft matter physics·2009

Same author

Electromechanics of fluidized beds of nanoparticles.

Physical review. E, Statistical, nonlinear, and soft matter physics·2009

Search research articles

Related Experiment Video

Updated: Jul 7, 2026

Covalent Immobilization of Proteins for the Single Molecule Force Spectroscopy

Covalent Immobilization of Proteins for the Single Molecule Force Spectroscopy

Published on: August 20, 2018

A calibration method for lateral forces for use with colloidal probe force microscopy cantilevers.

M A S Quintanilla¹, D T Goddard

¹Nexia Solutions Ltd., Springfields, Salwick, Preston, Lancashire PR4 0XJ, United Kingdom. quintani@us.es

The Review of Scientific Instruments

|March 5, 2008

Summary

A new calibration method quantifies friction force measurements from colloidal probe cantilevers using lateral force microscopy (LFM). This technique adapts existing methods and assesses error sources for accurate nanoscale friction analysis.

More Related Videos

Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy

Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy

Published on: July 18, 2014

Extracting the Young's Modulus of Native Murine Pulmonary Basement Membranes from Atomic Force Microscopy Derived Force Maps

Extracting the Young's Modulus of Native Murine Pulmonary Basement Membranes from Atomic Force Microscopy Derived Force Maps

Published on: January 31, 2025

Related Experiment Videos

Last Updated: Jul 7, 2026

Covalent Immobilization of Proteins for the Single Molecule Force Spectroscopy

Covalent Immobilization of Proteins for the Single Molecule Force Spectroscopy

Published on: August 20, 2018

Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy

Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy

Published on: July 18, 2014

Extracting the Young's Modulus of Native Murine Pulmonary Basement Membranes from Atomic Force Microscopy Derived Force Maps

Extracting the Young's Modulus of Native Murine Pulmonary Basement Membranes from Atomic Force Microscopy Derived Force Maps

Published on: January 31, 2025

Area of Science:

Materials Science
Surface Science
Nanotechnology

Background:

Lateral Force Microscopy (LFM) is crucial for nanoscale friction analysis.
Quantifying friction forces requires accurate cantilever calibration.
Existing calibration methods have limitations in precision and applicability.

Purpose of the Study:

To develop and validate a robust calibration method for colloidal probe cantilevers in LFM.
To enable accurate quantification of friction forces in surface interaction studies.
To assess and mitigate sources of error in LFM friction measurements.

Main Methods:

Adaptation of the Feiler et al. lever method for colloidal probe cantilevers.
Utilizing offset probe particle positioning for enhanced calibration.
Assessment of cantilever misalignment effects on torsional stiffness and lateral sensitivity.
Testing the method on flat substrates with glass beads and UO3 agglomerates on silicon cantilevers.

Main Results:

The developed method enables quantitative friction force measurements using LFM.
Cantilever misalignment significantly impacts torsional stiffness but not lateral photodiode sensitivity.
The calibration method is validated for use on flat substrates like glass, mica, and UO2 single crystals.
Comparison with the Cain et al. lateral compliance method demonstrates method validity.

Conclusions:

The proposed calibration method provides a reliable approach for quantifying friction forces with colloidal probe cantilevers.
Understanding and accounting for cantilever alignment is critical for accurate LFM measurements.
This method enhances the precision of nanoscale friction studies on various flat surfaces.