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Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

Asthma III: Clinical Manifestations

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

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Related Experiment Video

Updated: Jul 7, 2026

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Editorial: Experimental models of asthma.

Armin Braun¹, Thomas Tschernig, David A Groneberg

¹Fraunhofer Institute of Toxicology and Experimental Medicine, D-30625 Hannover, Germany. braun@item.fraunhofer.de.

Journal of Occupational Medicine and Toxicology (London, England)

|March 5, 2008

Summary

Annual workshops on asthma in animal models foster scientific exchange on respiratory diseases. Discussions cover methods, infections, environmental factors, and new COPD and asthma therapies.

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Area of Science:

Pulmonary Medicine
Immunology
Toxicology

Background:

The "Asthma in animal models" workshop has convened annually in Hannover, Germany, since 2002.
Organized by the Fraunhofer Institute of Toxicology and Experimental Medicine and the collaborative research centre 587 (Hannover Medical School).
Focuses on fostering scientific exchange between academic and industrial researchers and clinicians.

Purpose of the Study:

To facilitate intensive scientific dialogue on asthma and Chronic Obstructive Pulmonary Disease (COPD).
To explore diverse topics within respiratory research, including methodological advancements.
To discuss the impact of infections and environmental factors on lung health and disease.

Main Methods:

Annual workshop format encouraging direct scientific exchange.
Collaborative research environment involving multiple institutions.
Discussions spanning various aspects of asthma and COPD research.

Main Results:

Facilitated over two decades of scientific exchange on asthma and COPD.
Broadened understanding of lung immune reactions in infection and allergy.
Explored diverse etiological factors and therapeutic strategies for respiratory diseases.

Conclusions:

The workshop serves as a vital platform for advancing research in asthma and COPD.
Continuous scientific dialogue is crucial for developing novel therapeutic strategies.
Interdisciplinary collaboration is key to addressing complex respiratory conditions.