Innate immune response in insects: recognition of bacterial peptidoglycan and amplification of its recognition signal
Chan-Hee Kim1, Ji-Won Park, Nam-Chul Ha
1National Research Laboratory of Defense Proteins, College of Pharmacy, Pusan National University, Busan, Korea.
Abstract:
The major cell wall components of bacteria are lipopolysaccharide, peptidoglycan, and teichoic acid. These molecules are known to trigger strong innate immune responses in the host. The molecular mechanisms by which the host recognizes the peptidoglycan of Gram-positive bacteria and amplifies this peptidoglycan recognition signals to mount an immune response remain largely unclear. Recent, elegant genetic and biochemical studies are revealing details of the molecular recognition mechanism and the signalling pathways triggered by bacterial peptidoglycan. Here we review recent progress in elucidating the molecular details of peptidoglycan recognition and its signalling pathways in insects. We also attempt to evaluate the importance of this issue for understanding innate immunity.
Related Concept Videos
Bacterial Signaling
Defense Against Bacterial Pathogens
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Regulation of Bacterial Virulence
Peptidoglycan Synthesis
Defenses Against Pathogens and Herbivores
The Antiviral System of Bacteria and Archaea: CRISPR


