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Related Experiment Video

Updated: Jul 7, 2026

Strategies for Study of Neuroprotection from Cold-preconditioning

Strategies for Study of Neuroprotection from Cold-preconditioning

Published on: September 2, 2010

Neuroprotection: Present and future.

Régis Bordet¹, Pierre Lestage, Brigitte Onteniente

¹EA1046-Département de Pharmacologie Médicale, Institut de Médecine Prédictive et de Recherche Thérapeutique, Faculté de Médecine de l'Université Lille 2 & Centre Hospitalier et Universitaire de Lille, Lille, France. r-bordet@chru-lille.fr

Therapie

|March 5, 2008

Summary

Researchers are shifting from neuroprotection to "disease modifiers" for brain diseases. This new concept broadens therapeutic approaches by focusing on clinical outcomes rather than cellular mechanisms.

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Last Updated: Jul 7, 2026

Strategies for Study of Neuroprotection from Cold-preconditioning

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Published on: September 2, 2010

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

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Published on: January 4, 2015

Area of Science:

Neuroscience
Neurology
Psychiatry

Background:

Brain disease treatments utilize preventive, symptomatic, or etiopathogenic strategies.
Neuroprotection was initially favored for etiopathogenic approaches due to observed neuronal death.
Failures in developing neuroprotective agents led to the
Main_Methods
Main_Results
Conclusions

Purpose of the Study:

To explore the concept of
disease modifiers
in the context of brain disease treatment.

Main Methods:

Conceptual analysis of therapeutic approaches.
Review of clinical endpoints in disease modification.
Discussion of the implications for etiopathogenic treatments.

Main Results:

The
disease modifier
concept shifts focus from cellular mechanisms to clinical outcomes.
This approach allows broader application of etiopathogenic treatments.
Formalization of disease modification opens new avenues for research and therapy.

Conclusions:

The
disease modifier
concept represents a paradigm shift in treating brain diseases.
It facilitates the development and application of more effective therapies.
This conceptualization is crucial for advancing neurological and psychiatric treatments.