Neuroprotection: Present and future

Area of Science:

• Neuroscience
• Neurology
• Psychiatry

Background:

• Brain disease treatments utilize preventive, symptomatic, or etiopathogenic strategies.
• Neuroprotection was initially favored for etiopathogenic approaches due to observed neuronal death.
• Failures in developing neuroprotective agents led to the
• Main_Methods
• Main_Results
• Conclusions

Purpose of the Study:

• To explore the concept of
• disease modifiers
• in the context of brain disease treatment.

Main Methods:

• Conceptual analysis of therapeutic approaches.
• Review of clinical endpoints in disease modification.
• Discussion of the implications for etiopathogenic treatments.

Main Results:

• The
• disease modifier
• concept shifts focus from cellular mechanisms to clinical outcomes.
• This approach allows broader application of etiopathogenic treatments.
• Formalization of disease modification opens new avenues for research and therapy.

Conclusions:

• The
• disease modifier
• concept represents a paradigm shift in treating brain diseases.
• It facilitates the development and application of more effective therapies.
• This conceptualization is crucial for advancing neurological and psychiatric treatments.