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Updated: Jul 7, 2026

Characterization of the Sense of Agency over the Actions of Neural-machine Interface-operated Prostheses
Published on: January 7, 2019
Allowing autonomous agents freedom
1Institute of Medicine Law and Bioethics and Institute of Science Ethics and Innovation, School of Law, University of Manchester, Oxford Road, Manchester M13 9PL, UK. Antonia.Cronin@postgrad.manchester.ac.uk
Abstract:
Living-donor kidney transplantation is the "gold standard" treatment for many individuals with end-stage renal failure. Superior outcomes for the graft and the transplant recipient have prompted the implementation of new strategies promoting living-donor kidney transplantation, and the number of such transplants has increased considerably over recent years. Living donors are undoubtedly exposed to risk. In his editorial "underestimating the risk in living kidney donation", Walter Glannon suggests that more data on long-term outcomes for living donors are needed to determine whether this risk is permissible and the extent to which physicians and transplant surgeons should promote living-donor kidney transplantation. In this paper I argue that it is not clear that medical professionals have underestimated this risk, nor is it clear that more data on long-term outcomes are needed in order to determine whether it is permissible for individual autonomous agents to expose themselves to this or, indeed, any risk. The global shortage of organs available for transplantation ultimately means that every year thousands of individuals who value their life die needlessly. This is an unacceptable loss of human life. Saving life is one of the most wonderful things an individual can do for another. Promoting any strategy that will assist in saving life and preventing human suffering within acceptable moral limits is legitimate.
Insights
Living-donor kidney transplantation offers superior outcomes but carries risks for donors. This analysis questions the need for more long-term donor data, arguing that promoting life-saving transplants is ethically permissible.
Area of Science:
- Nephrology
- Transplant Surgery
- Bioethics
Background:
- Living-donor kidney transplantation is the preferred treatment for end-stage renal failure, with increasing numbers of procedures performed.
- While beneficial for recipients, living kidney donation involves inherent risks to the donor.
- Debate exists on whether the risks to living donors are adequately understood and if more long-term outcome data is necessary.
Purpose of the Study:
- To critically evaluate the assertion that medical professionals have underestimated the risks associated with living kidney donation.
- To determine if extensive long-term outcome data is essential for assessing the permissibility of living donation risks.
- To address the ethical considerations of promoting living-donor kidney transplantation amidst a global organ shortage.
Main Methods:
- Philosophical argumentation and ethical analysis.
- Critique of existing perspectives on risk assessment in living donation.
- Examination of the ethical imperative to save lives versus donor risk.
Main Results:
- It is not definitively established that the risks of living kidney donation have been underestimated.
- The necessity of additional long-term donor outcome data to permit individual risk-taking is questionable.
- The ethical permissibility of promoting life-saving interventions, like living-donor transplantation, is supported.
Conclusions:
- The ethical justification for promoting living-donor kidney transplantation does not solely depend on exhaustive long-term donor data.
- The significant loss of life due to organ shortages necessitates the promotion of transplantation within acceptable ethical bounds.
- Saving lives through living donation is a morally commendable act that should be encouraged.
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