[Establishment of transplantable HL-60 xenograft lines in athymic nude mice]

In vivo models of HL-60 cells were successfully established as ascites and/or solid forms in nude mice (BALB/c, nu/nu). HL-60 ascites and solid tumor cells produced 100% lethal takes after their 7th transplant generation and were stabilized at serial transplant intervals of 14 and 40 days respectively. Morphological studies demonstrated that the ascites and solid tumor cells exhibited morphological characteristics similar to those of HL-60 cells in vitro. The establishment of transplantable HL-60 xenograft lines provides a potential tool for the screening of effective differentiation inducers.